There are several possible reasons why buttons and their functions end up grayed-out or disabled:
1. If you have edited or modified the file in one way or another, you first need to save the file to commit the changes, or close the file (without saving) and reopen it, before the functions will be enabled again.
2. Upon opening a file, Delimit must complete a full file scan before all functions become enabled. If file scan is still running (or if it has paused) the functions will be grayed-out/disabled until the scan completes. Allow the full scan to complete (by un-pausing the scan if necessary) upon which the buttons will become enabled.
3. Upon opening a file, if Delimit detects certain unsupported and/or non-displayable characters (like NULL characters) in the file, Delimit will prompt you to have these replaced by another character. If you select not to have such characters replaced then all Delimit functions will be grayed-out or disabled.